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New genetic link reveals some ovarian cancer passed down by fathers

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A previously unrecognized link has been found between ovarian cancer and a gene on the X chromosome, according to a new study.

The finding, which reveals that a father's genes play an important role in a woman's ovarian cancer risk, could change the way doctors look for and treat one of the most lethal types of cancer.
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The gene, called MAGEC3, is still under investigation by scientists. A normal version is thought to be protective against tumor formation, according to the study, which was published last week in the journal PLOS Genetics. However, mutations may result in the unrestrained growth and reproduction of cells, leading to cancer.

Ovarian cancer has a five-year survival rate of approximately 45%, according to the American Cancer Society. In 2015, there were about 1.5 million cases of ovarian cancer worldwide and more than 161,000 deaths, making it the eighth most common cause of death from cancer.

"Ovarian cancer is sometimes called the silent killer. It's hard to detect, and it's hard to predict," said Kevin Eng, an associate professor of oncology at the Roswell Park Comprehensive Cancer Center and a leading author of the study.

Source :- ksat
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